Beckman Coulter Life Sciences, a Danaher company, is redefining nucleic acid quantification through a strategic collaboration with Hombrechtikon Systems Engineering•AG (HSE•AG), a Swiss provider of customized automation and engineering solutions for life sciences and diagnostics.

The partnership updates and miniaturizes traditional nucleic acid quantification, powered by an automation-first approach that integrates high-throughput liquid handling directly into molecular biology workflows. By streamlining critical processes—from normalization to yield characterization—it bridges existing workflow gaps and empowers real-time, data-driven decision-making within a unified platform. Automated pipetting is seamlessly embedded as a functional extension of the system’s ecosystem, driving efficiency and precision at scale.

Integrating the HSE eviDense UV Photometer directly onto the Biomek i-Series automated workstations deck from Beckman Coulter Life Sciences enables real-time absorbance measurements seamlessly within the liquid handling process to deliver faster, more efficient results while eliminating manual intervention. This technique precisely measures nucleic acid concentration and purity at 260/280 and 260/230 nanometer ratios. The non-destructive analysis allows valuable sample volume to be immediately recovered or advanced through the workflow based on user needs. Designed as a drop-in replacement, the instrument integrates effortlessly into established workflows and protocols, using proven methods to automate and close existing process gaps.

“Time is the most critical facet in the laboratory today, and we’re always examining workflows to see how we can help laboratories achieve results faster with greater accuracy,” said Ewan Grant, senior director of the Biotech Business Unit at Beckman Coulter Life Sciences. “This collaboration is a major step forward in advancing nucleic acid quantification. By enabling this workflow to be executed through a liquid handler, we’re uniquely able to help laboratories maximize walk-away time for both extraction and NGS library preparation, empowering researchers to get the answers they seek faster.”

The partnership also simplifies fluorometric analysis of nucleic acid quantification, delivering results in as little as 20 minutes for 96 samples. By integrating the HSE eviFluor Duo microcuvette-based fluorometer on the deck of a Biomek i-Series Automated Workstation from Beckman Coulter Life Sciences, laboratories gain access to a fully automated, end-to-end sample preparation solution. This system enables real-time data generation for immediate, decision-based pipetting—dramatically increasing speed and precision while eliminating manual, error-prone and time-consuming steps.

“The collaboration between Beckman Coulter Life Sciences and HSE marks a significant advancement in lab automation,” HSE Chief Technology Officer Konstantin Lutze stated. “With the integration of the eviDense UV Photometer and the eviFluor Duo Fluorometer into the Biomek i5 and i7 workstations, both absorbance and fluorescence measurements are performed fully automatically within the liquid handling workflow. This enables highly efficient nucleic acid quantification while enhancing data integrity and measurement consistency. By eliminating manual interactions, the risk of user-induced errors is minimized. Together, we support laboratories in achieving greater efficiency, reliability, and scalability through fully integrated, automated workflows.”

These two innovations empower research laboratories to accelerate drug discovery, reduce manual workload, and improve data reliability across genomic workflows, bringing researchers one step closer to the answers that matter most.

The product not intended or validated for use in diagnosing diseases or other conditions.

Beckman Coulter Life Sciences accelerates answers to critical questions through efficiency, saving hours from some workflows and delivering reliable results in centrifugation, flow cytometry, genomic solutions, particle analysis/counters, and liquid handlers. The company develops innovations for scientists by scientists. More than 400,000 of its products currently deliver results in labs worldwide.

Danaher is a global life sciences and diagnostics innovator that accelerates the power of science and technology to improve human health. Danaher’s advanced science and technology and ability to innovate help enable faster, more accurate diagnoses and help reduce the time and cost needed to sustainably discover, develop and deliver life-changing therapies. Focused on scientific excellence, innovation and continuous improvement, the company’s 63,000 associates worldwide help ensure that Danaher is improving quality of life for patients.

In today’s rapidly evolving life sciences landscape, HSE•AG offers technical consulting and engineering services, providing expertise in designing and industrializing asutomated solutions tailored to the complex demands of molecular, protein, and cell biology analyses. The company collaborates closely with clients to drive innovation, streamline processes, and ensure long-term success in a competitive industry. In addition to client-specific development services, HSE•AG designs and manufactures proprietary products, resold by commercial partners, to optimize workflows in life science applications. By bridging the gap between biological-medical application expertise and engineering knowledge, the company creates automated systems optimized for use in life science research and diagnostics.